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The re-emergence of cannabis into mainstream society has happened at an unprecedented rate, and millions of Americans are already consuming hemp in USA and Canada or cannabis-based products on a regular basis.

And many people are benefitting from the non-psychoactive properties of the plants, namely cannabidiol (CBD). CBD is a component of cannabis that’s known as a cannabinoid, and initiates most of its effects on the body via the endocannabinoid system (ECS). However, CBD has been shown to interact with other receptors, as well.

Here are five key things you should know about CBD.

CBD is non-psychoactive

CBD is a non-psychoactive substance, separating itself from all of the other cannabis products on the market. Isolated CBD does not have psychotropic effects because of how it influences the ECS. The psychotropic delta-9-tetrahydrocannabinol (THC) is a CB1 receptor agonist, while CBD is an antagonist of the receptor, which impacts multiple psychological variables, including mood and appetite. CBD just doesn’t make the necessary interaction with the ECS to make psychoactive effects, hence why CBD users are so comfortable about using these products.

CBD regulates the endocannabinoid system

The ECS is heavily implicated in our physical and mental wellbeing, and as a regulator of the ECS, CBD therefore fulfils a series of important functions. At the CB1 receptor, CBD indirectly helps to elevate mood via anandamide-mediated activation. Anandamide is an endocannabinoid that instigates antidepressant effects at CB1 receptors in the brain. To promote this effect, CBD restricts fatty acid amide hydrolase (FAAH) enzyme activity, which stops anandamide reuptake, making more available to bind with receptors.

At the CB2 receptor, CBD’s regulatory properties extend to immune system response. These receptors are well-proliferated throughout the peripheral nervous system. Anandamide and 2-Arachidonoylglycerol (2-AG) are the key endocannabinoids that bind with these receptors. CBD increases anandamide availability, and possibly affects 2-AG levels in ways not yet understood.

CBD-infused creams are beneficial for skin

The skin can benefit from CBD in many ways, and myriad of infused skin-based products have popped onto the market of late. The skin contains cannabinoid receptors, and particularly the CB2 variety, as well as vanilloid (TRPV-1) receptors that are involved with sensitivity to pain.

Agonising the CB2 receptors with endocannabinoids helps to regulate and reduce levels of inflammation, which is crucial for managing conditions like acne, and also rosacea. When an injury has occurred, excessive inflammation can cause large swelling – this can also be moderated with CBD creams.

Furthermore, Select CBD creams can work very well as localized pain relievers, soothing specific areas of the body that become overwhelmed with chronic, inflammatory and neuropathic pain. CBD is a vanilloid receptor agonist, and triggering these receptors appears critical to the analgesic properties of CBD. However, it’s possible that the CB1 receptor is part of the process, too.

CBD can improve physical health

CBD can improve all-round physical health, for both people with certain disorders, and those who are taking CBD for supplemental purposes to enhance general wellness.

CBD interferes with cortisol production, and therefore has a reductive effect on overall levels. This can be helpful when lifting weights at the gym, as lower amounts of cortisol facilitate increased muscle growth. This is because cortisol is a catabolic hormone that eats away at the muscle. Less cortisol tips the body’s hormonal balance in favor of testosterone, a hormone which allows for muscle growth.

CBD can improve mental health

The mental health benefits of CBD go sharply against the previous consensus on cannabis, which suggested the plant was bad news for psychological wellbeing. However, our 21st century understanding of weed presents a much more complex picture of the herb – instead of being a single entity, cannabis is made up of several hundred compounds. On its own, CBD can be very beneficial for anxiety, depression, and even psychosis and schizophrenia.

The calming effect that CBD has on anxiety comes from boosting activity among GABA neurotransmitters. Taking a CBD vape oil wholesale product quickly alters brain chemistry, alleviating anxiety.

The antidepressant effects of CBD are likely to be less about changing the chemical balance in the brain, and more to do with addressing brain inflammation, which affects the prefrontal cortex, hippocampus, amygdala and more. CBD supports neurogenesis and can heal damaged circuitry in these regions, restoring optimum brain health and managing treatment-resistant depression.

The value of CBD for psychosis and schizophrenia comes from the compound’s anti-psychotic properties. It was already well-documented that cannabis strains with higher concentrations of CBD were less psychoactive, and this is thanks to CBD being an antagonist of the CB1 receptor in the ECS.

CBD (cannabidiol) formula

Is CBD Legal?

The DEA (Drug Enforcement Administration in USA) has explicitly clarified time ago that CBD is banned from use on federal level along with the whole cannabis plant, yet has removed it in September 2018 from the Schedule I to Schedule V of the Controlled Substances Act.

At the same time CBD is allowed for distribution in 44 states already, and, for example, the federal Court in California has recently ordered the DEA to stop chasing medical marijuana traders who act legally by the laws of the state. Practically CBD medicine are widely offered in states where the recreational use of cannabis is allowed, namely California, Washington, Oregon, Colorado and Alaska. In case of doubt, just ask your provider if any interstate or international sending is expected for the purchased goods, I’m sure they all know the most recent changes and regulations.